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Electron transport chain of mitochondria carries electrons from universal electron donors such as FADH2 and NADH to O2 via enzyme complexes I, II, III and IV and produces ATP in complex V (Lehninger et al ., 2008)

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Embodiment A69 (a further embodiment of Embodiment A1) provides a compound that is (2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one